Diazomethane → HCID 20528716, compound

HRID 67175Notes

Reaction equation

HRID 67175 reaction equation
[C:1]([C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([NH:9][C:10](=[O:11])[C:5]=12)=[O:8])([OH:3])=[O:2].[N+](=[CH2:17])=[N-]>CCOCC>[CH3:17][O:2][C:1]([C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([NH:9][C:10](=[O:11])[C:5]=12)=[O:8])=[O:3]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 205447191,3-dioxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

Product 1

HCID 20528716HCID 20528716, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a suspension of 3-carboxyphthalimide (10 g) in ether (50 ml), a solution of diazomethane in ether was added slowly until a faint yellow colouration persisted. Excess of diazomethane was destroyed with acetic acid and the reaction mixture was evaporated to yield the desired compound.

Workup

  1. customExcess of diazomethane was destroyed with acetic acid
  2. customthe reaction mixture was evaporated

Sources & evidence

ORD record
ord-76be70ed1a3f490eb78799c7bb42183a
Source dataset
uspto-grants-1982_08
Patent number
US04345071

Reaction notes

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