3,5-Dimethoxybenzaldehyde → [3-(Tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-(3,5-dimethoxyphenyl)-methanol

HRID 671751Notes

Reaction equation

HRID 671751 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:16][CH3:17])[c:6]([O:7][Si:8]([CH3:9])([CH3:10])[C:11]([CH3:12])([CH3:13])[CH3:14])[cH:15]1.[CH2:18]([Li:19])[CH2:20][CH2:21][CH3:22].[CH3:23][O:24][c:25]1[cH:26][c:27]([CH:28]=[O:29])[cH:30][c:31]([O:33][CH3:34])[cH:32]1.[O:35]1[c:36]2[cH:37][cH:38][c:39]([CH:40]([c:41]3[cH:42][c:43]([O:44][CH3:45])[cH:46][c:47]([O:48][CH3:49])[cH:50]3)[OH:51])[cH:52][c:53]2[O:54][CH2:55][CH2:56]1>>[c:2]1([CH:28]([c:27]2[cH:26][c:25]([O:24][CH3:23])[cH:32][c:31]([O:33][CH3:34])[cH:30]2)[OH:29])[cH:3][cH:4][c:5]([O:16][CH3:17])[c:6]([O:7][Si:8]([CH3:9])([CH3:10])[C:11]([CH3:12])([CH3:13])[CH3:14])[cH:15]1

Participants

5

Reactant 4

HCID 817473,5-DimethoxybenzaldehydeHCID 109800492-(T-Butyldimethylsilyloxy)-4-bromoanisoleHCID 69202534(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-(3,5-dimethoxyphenyl)methanolHCID 178418339Butyllithium

Product 1

HCID 69204033[3-(Tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-(3,5-dimethoxyphenyl)-methanol

Sources & evidence

ORD record
ord-c8e3a5a690b84af98b21d191295b29aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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