1-Butanol → tert-butyl N-[1-[5-bromo-3-(pyridine-3-carbonylamino)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidin-3-yl]-N-methylcarbamate

HRID 671846Notes

Reaction equation

HRID 671846 reaction equation
[Br:16][c:17]1[c:18]([F:35])[c:19]2[c:20]([n:21][cH:22]1)[nH:23][cH:24][c:25]2[NH:26][C:27]([c:28]1[cH:29][n:30][cH:31][cH:32][cH:33]1)=[O:34].[CH2:36]([OH:37])[CH2:38][CH2:39][CH3:40].[CH3:1][N:2]([C:3]([O:4][C:5]([CH3:6])([CH3:7])[CH3:8])=[O:9])[CH:10]1[CH2:11][NH:12][CH2:13][CH2:14][CH2:15]1>>[CH3:1][N:2]([C:3]([O:4][C:5]([CH3:6])([CH3:7])[CH3:8])=[O:9])[CH:10]1[CH2:11][N:12]([c:18]2[c:17]([Br:16])[cH:22][n:21][c:20]3[c:19]2[c:25]([NH:26][C:27]([c:28]2[cH:29][n:30][cH:31][cH:32][cH:33]2)=[O:34])[cH:24][nH:23]3)[CH2:13][CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 2631-ButanolHCID 22449166tert-butyl N-methyl-N-(piperidin-3-yl)carbamateHCID 60205277N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)nicotinamide

Product 1

HCID 60205328tert-butyl N-[1-[5-bromo-3-(pyridine-3-carbonylamino)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidin-3-yl]-N-methylcarbamate

Sources & evidence

ORD record
ord-264715a6e343408b95676907f7796cf2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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