反应详情

To a solution of 2-acetyl-2-fluoro-6-(trimethylsilyl)-5-hexynoic acid ethyl ester (6.63 g) in ethanol (20 ml) was added 27 ml of 2.65 M sodium ethoxide/ethanol. After 18 hours, 7 ml of 4 N sodium hydroxide was added. After 6 hours, the solvent was removed by rotary evaporation and the residual materials partitioned between ethyl ether and dilute hydrochloric acid. The organic layer was dried (MgSO4) and the solvent removed by rotary evaporation to give an oil which was vacuum distilled to yield 3.2 g of 2-fluoro-5-hexynoic acid; b.p. 118°/14 mmHg.

1. waitAfter 6 hours
2. customthe solvent was removed by rotary evaporation
3. customthe residual materials partitioned between ethyl ether and dilute hydrochloric acid
4. dry with materialThe organic layer was dried (MgSO4)
5. customthe solvent removed by rotary evaporation
6. customto give an oil which
7. distillationdistilled