Acetic Anhydride → 3-(4-Acetyloxyphenyl)glutaric anhydride

HRID 67202Notes

Reaction equation

HRID 67202 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:13][C:14]([OH:16])=[O:15])[CH2:9][C:10]([OH:12])=O)=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:9][C:10](=[O:12])[O:15][C:14](=[O:16])[CH2:13]2)=[CH:6][CH:7]=1)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 20528836HCID 20528836, compound

Product 1

HCID 128489843-(4-Acetyloxyphenyl)glutaric anhydride

Procedure

A solution of 3-(4-hydroxyphenyl)glutaric acid (800 mg) in acetic anhydride (15 ml) is heated at 100° C. for 2.5 hours and evaporated to dryness in vacuo. The residual solid is crystallized from chloroform-hexane to afford 600 mg of 3-(4-acetyloxyphenyl)glutaric anhydride, melting point 140°-143° C.

Workup

  1. customevaporated to dryness in vacuo
  2. customThe residual solid is crystallized from chloroform-hexane

Sources & evidence

ORD record
ord-0ea97d537b3d40f58c323346375db763
Source dataset
uspto-grants-1982_08
Patent number
US04345096

Reaction notes

Loading…