反应详情

A solution of 750 mg. of 1-(3-(trifluoromethyl)phenyl)-5-chloro-2,3-dihydro-3-methyl-2-oxo-1H-imidazole-4-carboxaldehyde from Example 14 and 15 ml. of 25% aqueous dimethylamine was warmed on a steam bath for 5 minutes. The solution was cooled and the solid was collected by filtration and recrystallized from ethanol-water. After drying the product at 50° C. for 30 minutes, 320 mg. of 1-(3-(trifluoromethyl)phenyl)-5-chloro-2,3-dihydro-3-methyl-2-oxo-1H-imidazole-4-carboxaldehyde was recovered. M.P. 87°-90° C.

1. temperatureThe solution was cooled
2. filtrationthe solid was collected by filtration
3. customrecrystallized from ethanol-water
4. customAfter drying the product at 50° C. for 30 minutes
5. customof 1-(3-(trifluoromethyl)phenyl)-5-chloro-2,3-dihydro-3-methyl-2-oxo-1H-imidazole-4-carboxaldehyde was recovered