HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-[4-(Tert-butyldimethylsilanyloxy)-3-chlorophenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 3-Chloro-4-hydroxyphenylacetamide | HCID 15038375 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-[4-(Tert-butyldimethylsilanyloxy)-3-chlorophenyl]acetamide | HCID 22018507 | 77.4% |
Reaction Steps
A solution of 2-(3-chloro-4-hydroxy-phenyl)-acetamide (100 mg), imidazole (184 mg), and tert-butyldimethylsilyl chloride (163 mg) was stirred for 2 h in 5 mL of dimethylformamide. The solution was diluted with 50 mL of ethyl acetate and washed with 50 mL of sodium carbonate. The ethyl acetate was evaporated to afford 125 mg of 2-[4-(tert-butyldimethylsilanyloxy)-3-chlorophenyl]acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07084154B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-2e6609cbcbab46a8a867933955519b54 |
| Source note | uspto-grants-2006_08 |