Sodium borohydride → HCID 20492986, compound

HRID 67279Notes

Reaction equation

HRID 67279 reaction equation
[Br:1][C:2]([Br:14])(Br)[C:3]([C@H:5]1[C:7]([CH3:9])([CH3:8])[C@H:6]1[C:10]([OH:12])=[O:11])=O.[BH4-].[Na+]>O>[Br:1][CH:2]([Br:14])[CH:3]1[CH:5]2[CH:6]([C:7]2([CH3:9])[CH3:8])[C:10](=[O:12])[O:11]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22822821HCID 22822821, compound

Product 1

HCID 20492986HCID 20492986, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Cis 2-tribromoacetyl-3,3-dimethylcyclopropane carboxylic acid (0.2 mmol) prepared by a method analogous to that described in Example 1, was stirred for 10 minutes with a solution of sodium borohydride (0.8 mmol) in 5 ml water at room temperature for 16 hours and the crystalline reaction product was then filtered off and dried under reduced pressure at 40° C. The resulting product weighed 13 mg and contained 50% of the desired product, largely in the form of the endo isomer.

Workup

  1. filtrationthe crystalline reaction product was then filtered off
  2. customdried under reduced pressure at 40° C

Sources & evidence

ORD record
ord-9c08342e572b4bdcb413db91c5a4ba6b
Source dataset
uspto-grants-1982_08
Patent number
US04346038

Reaction notes

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