Ochratoxin A → 2-Hydroxy-4-methylbenzene-1,3-dioic acid

HRID 67281Notes

Reaction equation

C[C@H]1[O:12][C:10](=[O:11])[C:9]2[C:4](=[C:5](Cl)[CH:6]=[C:7]([C:14](N[C@H](C(O)=O)CC3C=CC=CC=3)=[O:15])[C:8]=2[OH:13])[CH2:3]1.C[O:30]C(C(C(OC)=O)CC(=O)CC)=O.OC=CC(=O)C.[Na]>>[OH:13][C:8]1[C:9]([C:10]([OH:12])=[O:11])=[C:4]([CH3:3])[CH:5]=[CH:6][C:7]=1[C:14]([OH:15])=[O:30]

Participants

Reactant 3

HCID 442530Ochratoxin A

HCID 20526893HCID 20526893, compound

HCID 86738543HCID 86738543, compound

Product 1

HCID 131393602-Hydroxy-4-methylbenzene-1,3-dioic acid

Procedure

A method of synthesis of Ochratoxin A comprising: reacting dimethyl-3-oxo-pentane-dicarboxylate with sodium hydroxymethyleneacetone to provide the dimethyl ester of 2-hydroxy-4-methylbenzene-1,3-dioic acid;

Sources & evidence

ORD record: ord-e3f4e273277040d2ab2012533c1a7213
Source dataset: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04346039

Reaction notes

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