7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → 7-[3-[(Cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

HRID 673059Notes

Reaction equation

HRID 673059 reaction equation
[CH:25]1([NH:28][CH2:29][CH:30]2[CH2:31][NH:32][CH2:33][CH:34]2[F:35])[CH2:26][CH2:27]1.[Cl:1][c:2]1[c:3]([F:24])[cH:4][c:5]2[c:6](=[O:23])[c:7]([C:20](=[O:21])[OH:22])[cH:8][n:9](-[c:12]3[c:13]([F:19])[cH:14][c:15]([F:18])[cH:16][cH:17]3)[c:10]2[n:11]1>>[c:2]1([N:32]2[CH2:31][CH:30]([CH2:29][NH:28][CH:25]3[CH2:26][CH2:27]3)[CH:34]([F:35])[CH2:33]2)[c:3]([F:24])[cH:4][c:5]2[c:6](=[O:23])[c:7]([C:20](=[O:21])[OH:22])[cH:8][n:9](-[c:12]3[c:13]([F:19])[cH:14][c:15]([F:18])[cH:16][cH:17]3)[c:10]2[n:11]1

Participants

3

Reactant 2

HCID 105460847-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidHCID 230620733-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4S)-(9CI)

Product 1

HCID 231256947-[3-[(Cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-09d83e1990ed400ca45d05fe79498901
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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