1-(Methanesulfonyl)piperidin-4-amine → N-{2-Fluoro-3-[5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-2-furansulfonamide

HRID 673150Notes

Reaction equation

HRID 673150 reaction equation
[CH3:35][S:36](=[O:37])(=[O:38])[N:39]1[CH2:40][CH2:41][CH:42]([NH2:45])[CH2:43][CH2:44]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:34])[c:21]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[o:30][cH:31][cH:32][cH:33]4)[cH:22][cH:23][cH:24]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1>>[c:2]1([NH:45][CH:42]2[CH2:41][CH2:40][N:39]([S:36]([CH3:35])(=[O:37])=[O:38])[CH2:44][CH2:43]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:34])[c:21]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[o:30][cH:31][cH:32][cH:33]4)[cH:22][cH:23][cH:24]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 113558261-(Methanesulfonyl)piperidin-4-amineHCID 57989659N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-furansulfonamide

Product 1

HCID 57989919N-{2-Fluoro-3-[5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-2-furansulfonamide

Sources & evidence

ORD record
ord-2e7ca03cf57e42119e592d5d181f5401
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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