Ethanol → Tert-butyl 4-(2-chloro-4-hydroxyphenyl)-piperazine-1-carboxylate

HRID 673230Notes

Reaction equation

HRID 673230 reaction equation
[CH3:45][CH2:46][OH:47].[Cl:1][c:2]1[c:3]([N:15]2[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]2)[cH:4][cH:5][c:6]([O:8][CH:9]2[CH2:10][CH2:11][CH2:12][CH2:13][O:14]2)[cH:7]1.[c:28]1([CH3:29])[cH:30][cH:31][c:32]([S:33]([O-:34])(=[O:35])=[O:36])[cH:37][cH:38]1.[nH+:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1>>[Cl:1][c:2]1[c:3]([N:15]2[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]2)[cH:4][cH:5][c:6]([OH:8])[cH:7]1

Participants

5

Reactant 4

HCID 702EthanolHCID 85570p-ToluenesulfonateHCID 4989215PyridiniumHCID 23081313Tert-butyl 4-[2-chloro-4-(tetrahydropyran-2-yloxy)phenyl]piperazine-1-carboxylate

Product 1

HCID 23081264Tert-butyl 4-(2-chloro-4-hydroxyphenyl)-piperazine-1-carboxylate

Sources & evidence

ORD record
ord-d438d3b1d13c45a598a8dda901525e51
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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