5-(4-Chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidine → 2-(4-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

HRID 673663Notes

Reaction equation

HRID 673663 reaction equation
[C:21](#[CH:22])[c:23]1[cH:24][cH:25][c:26]([C:29]([CH3:30])([CH3:31])[OH:32])[cH:27][cH:28]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[I:20])[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[C:22]#[C:21][c:23]2[cH:24][cH:25][c:26]([C:29]([CH3:30])([CH3:31])[OH:32])[cH:27][cH:28]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 670008755-(4-Chloro-phenyl)-7-cyclopropyl-3-iodo-pyrazolo[1,5-a]pyrimidineHCID 730124462-(4-Ethynylphenyl)propan-2-ol

Product 1

HCID 118522182-(4-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-phenyl}-propan-2-ol

Sources & evidence

ORD record
ord-4049b42cae0e462ab3a1591ddda7bb99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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