Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate → 4-(2-Cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

HRID 673780Notes

Reaction equation

HRID 673780 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][nH:8][c:9]2[c:10]1[n:11][cH:12][n:13][c:14]2[Cl:15].[CH:16]1([CH2:19][O:20][c:21]2[c:22]([B:30]3[O:31][C:32]([CH3:33])([CH3:34])[C:35]([CH3:36])([CH3:37])[O:38]3)[cH:23][c:24]([O:28][CH3:29])[c:25]([F:27])[cH:26]2)[CH2:17][CH2:18]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][nH:8][c:9]2[c:10]1[n:11][cH:12][n:13][c:14]2-[c:22]1[c:21]([O:20][CH2:19][CH:16]2[CH2:17][CH2:18]2)[cH:26][c:25]([F:27])[c:24]([O:28][CH3:29])[cH:23]1

Participants

3

Reactant 2

HCID 52987614Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylateHCID 668663772-(2-Cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

Product 1

HCID 668677174-(2-Cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-699bb6a6bfa947c1bab1e0940effbef9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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