Methanol → tert-butyl 4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(hydrazinocarbonyl)piperidine-1-carboxylate

HRID 674801Notes

Reaction equation

HRID 674801 reaction equation
[CH2:1]([O:2][C:3](=[O:4])[NH:11][NH:12][C:13](=[O:14])[C:15]1([CH2:28][c:29]2[n:30][c:31]([NH:35][c:36]3[cH:37][cH:38][n:39][n:40]3[C:41]([CH3:42])([CH3:43])[CH3:44])[cH:32][cH:33][cH:34]2)[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]1)[c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[CH3:45][OH:46].[OH-:47].[OH-:49].[Pd+2:48]>>[NH2:11][NH:12][C:13](=[O:14])[C:15]1([CH2:28][c:29]2[n:30][c:31]([NH:35][c:36]3[cH:37][cH:38][n:39][n:40]3[C:41]([CH3:42])([CH3:43])[CH3:44])[cH:32][cH:33][cH:34]2)[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 66889476tert-butyl 4-((2-((benzyloxy)carbonyl)hydrazino)carbonyl)-4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)piperidine-1-carboxylate

Product 1

HCID 66889292tert-butyl 4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(hydrazinocarbonyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7619deb4421949e4a72571aa04a4dc3c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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