Acetate → Tert-butyl 3-(isoquinolin-5-ylamino)pyrrolidine-1-carboxylate

HRID 674858Notes

Reaction equation

HRID 674858 reaction equation
[Br:1][c:2]1[c:3]2[cH:4][cH:5][n:6][cH:7][c:8]2[cH:9][cH:10][cH:11]1.[C:25](=[O:26])([O-:27])[O-:28].[C:31]([O-:32])(=[O:33])[CH3:34].[C:36]([O-:37])(=[O:38])[CH3:39].[CH3:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[Cs+:29].[Cs+:30].[NH2:12][CH:13]1[CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]1.[Pd+2:35]>>[c:2]1([NH:12][CH:13]2[CH2:14][N:15]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:16][CH2:17]2)[c:3]2[cH:4][cH:5][n:6][cH:7][c:8]2[cH:9][cH:10][cH:11]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 7364875-BromoisoquinolineHCID 27563701-Boc-3-aminopyrrolidine

Product 1

HCID 23079381Tert-butyl 3-(isoquinolin-5-ylamino)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-a57b0f4974aa45718a7407054fdd0d20
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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