Water → 5-[[4-[4-[(2-Hydroxy-2-pyridin-3-ylethyl)amino]piperidin-1-yl]phenyl]methyl]-1,3-thiazolidine-2,4-dione

HRID 674910Notes

Reaction equation

HRID 674910 reaction equation
[Cl:33][CH2:34][Cl:35].[NH2:1][CH2:2][CH:3]([OH:4])[c:5]1[cH:6][n:7][cH:8][cH:9][cH:10]1.[O:11]=[C:12]1[CH2:13][CH2:14][N:15]([c:18]2[cH:19][cH:20][c:21]([CH2:22][CH:23]3[C:24](=[O:29])[NH:25][C:26](=[O:28])[S:27]3)[cH:30][cH:31]2)[CH2:16][CH2:17]1.[OH2:32]>>[NH:1]([CH2:2][CH:3]([OH:4])[c:5]1[cH:6][n:7][cH:8][cH:9][cH:10]1)[CH:12]1[CH2:13][CH2:14][N:15]([c:18]2[cH:19][cH:20][c:21]([CH2:22][CH:23]3[C:24](=[O:29])[NH:25][C:26](=[O:28])[S:27]3)[cH:30][cH:31]2)[CH2:16][CH2:17]1

Participants

5

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 37105942-Amino-1-(pyridin-3-yl)ethan-1-olHCID 129659555-[4-(4-Oxo-piperidin-1-yl)-benzyl]-thiazolidine-2,4-dione

Product 1

HCID 222202225-[[4-[4-[(2-Hydroxy-2-pyridin-3-ylethyl)amino]piperidin-1-yl]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Sources & evidence

ORD record
ord-0839d588fe874011bcb2b673c7307d6d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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