Methyl 4-hydroxy-1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate → Methyl 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylate

HRID 675095Notes

Reaction equation

HRID 675095 reaction equation
[Cl:17][CH:18]1[CH2:19][CH2:20][O:21][c:22]2[cH:23][c:24]([F:29])[cH:25][c:26]([F:28])[c:27]21.[OH:1][c:2]1[cH:3][c:4]([C:13](=[O:14])[O:15][CH3:16])[cH:5][c:6]2[n:7]([CH3:12])[c:8]([CH3:11])[n:9][c:10]12>>[O:1]([c:2]1[cH:3][c:4]([C:13](=[O:14])[O:15][CH3:16])[cH:5][c:6]2[n:7]([CH3:12])[c:8]([CH3:11])[n:9][c:10]12)[CH:18]1[CH2:19][CH2:20][O:21][c:22]2[cH:23][c:24]([F:29])[cH:25][c:26]([F:28])[c:27]21

Participants

3

Reactant 2

HCID 68690597Methyl 4-hydroxy-1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylateHCID 686921254-Chloro-5,7-difluorochromane

Product 1

HCID 68688755Methyl 4-[(5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy]-1,2-dimethyl-1H-benzimidazole-6-carboxylate

Sources & evidence

ORD record
ord-bb8022d9635c4ca0889a3def4cf8c928
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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