HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sarcosine → 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sarcosine | HCID 1088 | — |
| Reactant | 5-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 10487522 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione | HCID 21708975 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A mixture of 14.0 g (79 mmol) of 6-methylisatoic acid anhydride, 7.04 g (79 mmol) of sarcosine and 80 ml of dimethyl sulphoxide is stirred at 110° C. for 3 hours. The red coloured solution is evaporated in a high vacuum. The residue is treated with 80 ml of ethanol, the product crystallising out. There is obtained 3,4-dihydro-4,6-dimethyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 200°-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04346033 |
| Source dataset | uspto-grants-1982_08 |
| ORD ID | ord-30988b80aa0c4c2f810925a46d2cbe74 |
| Source note | uspto-grants-1982_08 |