2,2,2-Trifluoro-1-(4-iodophenyl)ethanol → 8-(Cyclopropylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 675618Notes

Reaction equation

HRID 675618 reaction equation
[CH:1]1([S:4](=[O:5])(=[O:6])[N:7]2[CH2:8][CH2:9][C:10]3([CH2:11][CH2:12][NH:13][C:14]3=[O:15])[CH2:16][CH2:17]2)[CH2:2][CH2:3]1.[F:18][C:19]([CH:20]([OH:21])[c:22]1[cH:23][cH:24][c:25]([I:28])[cH:26][cH:27]1)([F:29])[F:30]>>[CH:1]1([S:4](=[O:5])(=[O:6])[N:7]2[CH2:8][CH2:9][C:10]3([CH2:11][CH2:12][N:13]([c:25]4[cH:24][cH:23][c:22]([CH:20]([C:19]([F:18])([F:29])[F:30])[OH:21])[cH:27][cH:26]4)[C:14]3=[O:15])[CH2:16][CH2:17]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 594408652,2,2-Trifluoro-1-(4-iodophenyl)ethanolHCID 595779488-(Cyclopropylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 595779698-(Cyclopropylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-5a8fc330edc84812887076c55344c282
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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