6-Fluoro-1,2,3,4-tetrahydroisoquinoline → 4-(6-((6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-2-(2-methyl-1H-benzo[d]imidazol-1-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine

HRID 675695Notes

Reaction equation

HRID 675695 reaction equation
[CH3:1][c:2]1[n:3][c:4]2[c:5]([n:6]1-[c:7]1[n:8][c:9]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:10]3[c:11]([n:12]1)[cH:13][c:14]([CH:16]=[O:17])[s:15]3)[cH:24][cH:25][cH:26][cH:27]2.[F:28][c:29]1[cH:30][c:31]2[c:36]([cH:37][cH:38]1)[CH2:35][NH:34][CH2:33][CH2:32]2>>[CH3:1][c:2]1[n:3][c:4]2[c:5]([n:6]1-[c:7]1[n:8][c:9]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:10]3[c:11]([n:12]1)[cH:13][c:14]([CH2:16][N:34]1[CH2:33][CH2:32][c:31]4[cH:30][c:29]([F:28])[cH:38][cH:37][c:36]4[CH2:35]1)[s:15]3)[cH:24][cH:25][cH:26][cH:27]2

Participants

3

Reactant 2

HCID 157187246-Fluoro-1,2,3,4-tetrahydroisoquinolineHCID 866482462-(2-methyl-1H-benzo[d]imidazol-1-yl)-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 596059994-(6-((6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-2-(2-methyl-1H-benzo[d]imidazol-1-yl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Sources & evidence

ORD record
ord-7623e4b0ebb44e179a691832ecfc5b13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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