6-Chloro-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide → 6-({3-(Aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide

HRID 675750Notes

Reaction equation

HRID 675750 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[cH:8][c:9]([C:11](=[O:12])[NH:13][CH:14]([CH3:15])[CH3:16])[n:10]2.[NH2:17][c:18]1[s:19][c:20](-[c:26]2[c:27]([F:37])[cH:28][c:29]([C:33]([CH3:34])([CH3:35])[OH:36])[cH:30][c:31]2[F:32])[cH:21][c:22]1[C:23](=[O:24])[NH2:25]>>[c:2]1([NH:17][c:18]2[s:19][c:20](-[c:26]3[c:27]([F:37])[cH:28][c:29]([C:33]([CH3:34])([CH3:35])[OH:36])[cH:30][c:31]3[F:32])[cH:21][c:22]2[C:23](=[O:24])[NH2:25])[cH:3][cH:4][c:5]2[n:6]([n:7]1)[cH:8][c:9]([C:11](=[O:12])[NH:13][CH:14]([CH3:15])[CH3:16])[n:10]2

Participants

3

Reactant 2

HCID 582166346-Chloro-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamideHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 445529036-({3-(Aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)-N-isopropylimidazo[1,2-b]pyridazine-2-carboxamide

Sources & evidence

ORD record
ord-ad21dd65aeb84b9485f2c057cf75c35b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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