2-Cyanopyridine-5-boronic acid pinacol ester → 5-[1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]-pyridine-2-carbonitrile

HRID 676006Notes

Reaction equation

HRID 676006 reaction equation
[CH3:21][C:22]1([CH3:23])[C:24]([CH3:25])([CH3:26])[O:27][B:28]([c:29]2[cH:30][cH:31][c:32]([C:35]#[N:36])[n:33][cH:34]2)[O:37]1.[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13]([I:15])[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([F:20])[cH:18][cH:19]1>>[F:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:29]4[cH:30][cH:31][c:32]([C:35]#[N:36])[n:33][cH:34]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[cH:16][c:17]([F:20])[cH:18][cH:19]1

Participants

3

Reactant 2

HCID 164141882-Cyanopyridine-5-boronic acid pinacol esterHCID 578860131-(2,5-Difluorobenzyl)-7-iodo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Product 1

HCID 248533315-[1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]-pyridine-2-carbonitrile

Sources & evidence

ORD record
ord-6f0c9de0164e403995a6a67df7c1937c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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