Diethyl Ether → (4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-methyl-3-nitro-phenyl)-methanone

HRID 676360Notes

Reaction equation

HRID 676360 reaction equation
[Br:6][c:7]1[cH:8][n:9]([CH:17]([CH3:18])[CH3:19])[c:10]2[n:11][cH:12][n:13][c:14]([Cl:16])[c:15]12.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:36]([O:37][CH2:38][CH3:39])[CH3:40].[CH3:20][O:21][N:22]([C:23]([c:24]1[c:25]([CH3:33])[c:26]([N+:30](=[O:31])[O-:32])[cH:27][cH:28][cH:29]1)=[O:34])[CH3:35]>>[c:7]1([C:23]([c:24]2[c:25]([CH3:33])[c:26]([N+:30](=[O:31])[O-:32])[cH:27][cH:28][cH:29]2)=[O:34])[cH:8][n:9]([CH:17]([CH3:18])[CH3:19])[c:10]2[n:11][cH:12][n:13][c:14]([Cl:16])[c:15]12

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 15338107N-methoxy-N,2-dimethyl-3-nitrobenzamideHCID 457894285-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidineHCID 178418339Butyllithium

Product 1

HCID 86760551(4-Chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(2-methyl-3-nitro-phenyl)-methanone

Sources & evidence

ORD record
ord-c707856bb0c04eac93d5c8c1cc8e86eb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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