(2-(trifluoromethyl)phenyl)acetic acid → 1'-(2-(2-(Trifluoromethyl)phenyl)acetyl)spiro[indoline-3,4'-piperidin]-2-one
Reaction equation
[F:1][C:2]([c:3]1[c:4]([CH2:9][C:10](=[O:11])[OH:12])[cH:5][cH:6][cH:7][cH:8]1)([F:13])[F:14].[NH:15]1[CH2:16][CH2:17][C:18]2([C:19](=[O:27])[NH:20][c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]32)[CH2:28][CH2:29]1>>[F:1][C:2]([c:3]1[c:4]([CH2:9][C:10](=[O:12])[N:15]2[CH2:16][CH2:17][C:18]3([C:19](=[O:27])[NH:20][c:21]4[cH:22][cH:23][cH:24][cH:25][c:26]43)[CH2:28][CH2:29]2)[cH:5][cH:6][cH:7][cH:8]1)([F:13])[F:14]Participants
3
Sources & evidence
- ORD record
- ord-88bd1ed13078428ebaedaed16d8fcb34
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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