Antibiotic DC 11 → aldehydo-L-digitoxose

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Reaction Steps

The forementioned studies involved obtaining tetrocarcin A by dissolving DC-11 in ethyl acetate, washing the solution with dilute hydrochloric acid and subjecting the resulting solution to column chromatography using silica gel. The resulting tetrocarcin A is subjected to hydrolysis to obtain L-amicetose, L-digitoxose and a compound represented by the following formula: ##STR2## Based on the physicochemical properties of tetrocarcin A, DC-11 and antlermicin A (the free form of which is considered to be identical to tetrocarcin A; see J. Antibiotics, 33, 244-246, 1980) as shown in Table A below and the results of the hydrolysis above referred to, the above formula for tetrocarcin A was obtained.

Provenance & Evidence