Methyl acetoacetate → 4-dodecylaminoethylaminoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

HRID 67673Notes

Reaction equation

HRID 67673 reaction equation
[CH2:1]([NH:13][CH2:14][CH2:15][NH:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][NH2:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[C:23](OC)(=[O:28])[CH2:24][C:25]([CH3:27])=O>>[CH2:1]([NH:13][CH2:14][CH2:15][NH:16][CH2:17][CH2:18][N:19]1[C:23](=[O:28])[CH2:24][C:25]([CH3:27])=[N:22][CH2:21][CH2:20]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 7757Methyl acetoacetateHCID 14325615HCID 14325615, compound

Product 1

HCID 705507174-dodecylaminoethylaminoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

Procedure

Into an apparatus similar to that in Example 1, were charged 314.5 g (1 mole) of N-dodecyltriethylenetetramine and 116.1 g (1 mole) of methyl acetoacetate. At 140° to 150° C., 18 g of water and 32 g of methanol were distilled off to obtain 4-dodecylaminoethylaminoethyl-7-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.

Workup

  1. distillationAt 140° to 150° C., 18 g of water and 32 g of methanol were distilled off

Sources & evidence

ORD record
ord-ccf49ea98bb24db78b55c8c392c8f7fe
Source dataset
uspto-grants-1982_08
Patent number
US04346087

Reaction notes

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