Propanoic acid, 2-methyl-3-oxo-, methyl ester → 4-tetradecylaminoethyl-6-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

HRID 67675Notes

Reaction equation

HRID 67675 reaction equation
[CH2:1]([NH:15][CH2:16][CH2:17][NH:18][CH2:19][CH2:20][NH2:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[CH:22]([CH:24]([CH3:29])[C:25](OC)=O)=[O:23]>>[CH2:1]([NH:15][CH2:16][CH2:17][N:18]1[C:22](=[O:23])[CH:24]([CH3:29])[CH:25]=[N:21][CH2:20][CH2:19]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 103507Propanoic acid, 2-methyl-3-oxo-, methyl esterHCID 12803361N-tetradecyldiethylenetriamine

Product 1

HCID 128033624-tetradecylaminoethyl-6-methyl-3,6-dihydro-2H-1,4-diazepin-5-one

Procedure

Into an apparatus similar to that in Example 1, were charged 299.5 g (1 mole) of N-tetradecyldiethylenetriamine and 116.1 g (1 mole) of methyl 2-formylpropionate. At 130° to 135° C., 18 g of water and 32 g of methanol were distilled off to obtain 4-tetradecylaminoethyl-6-methyl-3,6-dihydro-2H-1,4-diazepin-5-one.

Workup

  1. distillationAt 130° to 135° C., 18 g of water and 32 g of methanol were distilled off

Sources & evidence

ORD record
ord-982f397b0dc2439d99d2ac4591c44886
Source dataset
uspto-grants-1982_08
Patent number
US04346087

Reaction notes

Loading…