Ethyl 4-oxobutanoate → 4-(2-Hydroxyhexadecyl)aminoethyl-2,3,6,7-tetrahydro-1,4-diazocin-5-one

HRID 67679Notes

Reaction equation

HRID 67679 reaction equation
[OH:1][CH:2]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][NH2:10].[CH:25]([CH2:27][CH2:28][C:29](OCC)=O)=[O:26]>>[OH:1][CH:2]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:3][NH:4][CH2:5][CH2:6][N:7]1[C:25](=[O:26])[CH2:27][CH2:28][CH:29]=[N:10][CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 82395Ethyl 4-oxobutanoateHCID 201483611-({2-[(2-Aminoethyl)amino]ethyl}amino)hexadecan-2-OL

Product 1

HCID 539747674-(2-Hydroxyhexadecyl)aminoethyl-2,3,6,7-tetrahydro-1,4-diazocin-5-one

Procedure

Into an apparatus similar to that in Example 1, were charged 339.5 g (1 mole) of N-(2-hydroxy)hexadecyldiethylenetriamine and 130.1 g (1 mole) of ethyl 3-formylpropionate. At 135° to 140° C., 18 g of water and 46 g of ethanol were distilled off to obtain 4-(2-hydroxyhexadecyl)aminoethyl-2,3,6,7-tetrahydro-1,4-diazocin-5-one.

Workup

  1. distillationAt 135° to 140° C., 18 g of water and 46 g of ethanol were distilled off

Sources & evidence

ORD record
ord-d0c0d2836a1b41e4bd379baedb9f96f0
Source dataset
uspto-grants-1982_08
Patent number
US04346087

Reaction notes

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