5-Methoxy-o-toluidine → N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(5-methoxy-2-methylphenyl)-2,4-pyrimidinediamine

HRID 676820Notes

Reaction equation

HRID 676820 reaction equation
[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([CH3:29])[c:26]([NH2:27])[cH:28]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:19])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:12]([cH:13][cH:14]2)[O:15][CH2:16][CH2:17][O:18]3)[n:7]1>>[c:2]1([NH:27][c:26]2[c:25]([CH3:29])[cH:24][cH:23][c:22]([O:21][CH3:20])[cH:28]2)[n:3][cH:4][c:5]([F:19])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:12]([cH:13][cH:14]2)[O:15][CH2:16][CH2:17][O:18]3)[n:7]1

Participants

3

Reactant 2

HCID 995005-Methoxy-o-toluidineHCID 220603622-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamine

Product 1

HCID 22061047N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(5-methoxy-2-methylphenyl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-21fb437a2e91430abcf26a4b388867cc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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