Bicarbonate Ion → 2-(3-fluoro-4-hydroxyphenylamino)-N-(4-fluorophenyl)nicotinamide
Reaction equation
[B:30]([Br:31])([Br:32])[Br:33].[Cl:27][CH2:28][Cl:29].[F:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[c:12]([C:13](=[O:14])[NH:15][c:16]3[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]3)[cH:23][cH:24][cH:25][n:26]2)[cH:5][cH:6][c:7]1[O:8][CH3:9].[Na+:38].[O-:34][C:35]([OH:36])=[O:37].[OH2:39]>>[F:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[c:12]([C:13](=[O:14])[NH:15][c:16]3[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]3)[cH:23][cH:24][cH:25][n:26]2)[cH:5][cH:6][c:7]1[OH:8]Participants
7
Sources & evidence
- ORD record
- ord-66496a5175f24d069a0749bbf4f3635a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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