HRID67715

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)c1cc(N)c2ccccc2c1O

HCID103328

2-Naphthalenecarboxamide, 4-amino-1-hydroxy-N,N-dioctadecyl-

C47H82N2O2

HCID20493237

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)C(=O)c1cc(NS(=O)(=O)c2ccc(S(=O)(=O)CCC#N)cc2)c2ccccc2c1O

HCID20493239

未命名化合物

收率 62%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A solution of 4-amino-1-hydroxy-N,N-dioctadecyl-2-naphthamide (U.S. Pat. No. 4,135,929) (0.03 mol) in 450 ml of degassed pyridine was cooled to 5° to 10° C. and 8.8 g (0.03 mol) of 4-(2-cyanoethylsulfonyl)benzenesulfonyl chloride was added scoopwise at 0° to 5° C. The mixture was stirred for one hour at this temperature and was warmed to 20° to 25° C. and held for one hour. The reaction mixture was drowned in 2 liters of ice and water, filtered, reslurried in water and dried. The product was recrystallized from hexane to give 18 g (62 percent) of a tan solid, melting point 85° to 86° C.

WORKUP

后处理

temperaturewas warmed to 20° to 25° C.
waitheld for one hour
filtrationwater, filtered
customdried
customThe product was recrystallized from hexane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5d8b53e8aa6f4261a74e8de51aef4cc1
来源数据集: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04346161
来源说明: uspto-grants-1982_08

反应 SMILES

[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([N:15]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:14])[CH:3]=1.[C:52]([CH2:54][CH2:55][S:56]([C:59]1[CH:64]=[CH:63][C:62]([S:65](Cl)(=[O:67])=[O:66])=[CH:61][CH:60]=1)(=[O:58])=[O:57])#[N:53]>N1C=CC=CC=1>[C:52]([CH2:54][CH2:55][S:56]([C:59]1[CH:64]=[CH:63][C:62]([S:65]([NH:1][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([OH:12])=[C:4]([C:13]([N:15]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:14])[CH:3]=2)(=[O:66])=[O:67])=[CH:61][CH:60]=1)(=[O:58])=[O:57])#[N:53]