Acetone → HCID 178482502, compound

HRID 67732Notes

Reaction equation

HRID 67732 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[CH3:7][C:8]([CH3:10])=O.[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>N1C=CC=CC=1>[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([N:5]2[C:8]([CH3:10])([CH3:7])[S:6][C:3]([NH:2][CH3:1])=[N:4]2)=[O:17])=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 678794-Fluorobenzoyl chlorideHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 178482502HCID 178482502, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 42 g. portion of 4-methylthiosemicarbazide was reacted with 400 ml. of acetone, and then with 32 ml. of pyridine and 63.6 g. of 4-fluorobenzoyl chloride, and the mixture was worked-up as described in Example 1. The product was recrystallized from 80 ml. of nitromethane to obtain 43 g. of the desired product, 138°-144°.

Workup

  1. customThe product was recrystallized from 80 ml
  2. customof nitromethane to obtain 43 g

Sources & evidence

ORD record
ord-ef2850b8af134026b3630bdb3e12e9a1
Source dataset
uspto-grants-1982_08
Patent number
US04346225

Reaction notes

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