Acetic Acid → 2-(4-Chloro-2-methylphenyl-imino)-4-(4-chloro-3-dimethylsulfamoylphenyl)-3-methyl-4-thiazoline hydrobromide

HRID 67757Notes

Reaction equation

[BrH:1].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]2[N:14]([CH3:15])[C:13]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([S:24](=[O:29])(=[O:28])[N:25]([CH3:27])[CH3:26])[CH:18]=3)(O)[CH2:12][S:11]2)=[CH:5][C:4]=1C.[C:31](O)(=O)C>>[BrH:1].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]=[C:10]2[N:14]([CH3:15])[C:13]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([S:24](=[O:28])(=[O:29])[N:25]([CH3:26])[CH3:27])[CH:18]=3)=[CH:12][S:11]2)=[C:7]([CH3:31])[CH:8]=1

Participants

Reactant 2

HCID 176Acetic Acid

HCID 705337682-(4-Chloro-3-methylphenyl-imino)-4-(4-chloro-3-dimethylsulfamoylphenyl)-3-methylthiazolidin-4-ol hydrobromide

Product 1

HCID 205271222-(4-Chloro-2-methylphenyl-imino)-4-(4-chloro-3-dimethylsulfamoylphenyl)-3-methyl-4-thiazoline hydrobromide

Procedure

Obtained by a procedure analogous to that indicated in Example 1 (b), from 2-(4-chloro-3-methylphenyl-imino)-4-(4-chloro-3-dimethylsulfamoylphenyl)-3-methylthiazolidin-4-ol hydrobromide in boiling glacial acetic acid, with subsequent precipitation with diethyl ether. Colorless crystals from glacial acetic acid; melting point 231° C. (with decomposition).

Workup

customObtained by a procedure analogous to
customwith subsequent precipitation with diethyl ether

Sources & evidence

ORD record: ord-32a1847127774ac48837e8c6685b575b
Source dataset: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04346088

Reaction notes

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