(RS)-Ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acid → (RS)-N-(3-chloro-4-cyano-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide

HRID 677613Notes

Reaction equation

HRID 677613 reaction equation
[CH2:1]([CH3:2])[O:3][CH:4]([C:5](=[O:6])[OH:7])[c:8]1[c:9]([F:16])[cH:10][c:11]([O:14][CH3:15])[cH:12][cH:13]1.[NH2:17][CH2:18][c:19]1[cH:20][c:21]([Cl:27])[c:22]([C:23]#[N:24])[cH:25][cH:26]1>>[CH2:1]([CH3:2])[O:3][CH:4]([C:5](=[O:7])[NH:17][CH2:18][c:19]1[cH:20][c:21]([Cl:27])[c:22]([C:23]#[N:24])[cH:25][cH:26]1)[c:8]1[c:9]([F:16])[cH:10][c:11]([O:14][CH3:15])[cH:12][cH:13]1

Participants

3

Reactant 2

HCID 21904991(RS)-Ethoxy-(2-fluoro-4-methoxy-phenyl)-acetic acidHCID 219057174-(Aminomethyl)-2-chlorobenzonitrile

Product 1

HCID 21905421(RS)-N-(3-chloro-4-cyano-benzyl)-2-ethoxy-2-(2-fluoro-4-methoxy-phenyl)-acetamide

Sources & evidence

ORD record
ord-9eb830f1bdbc4ca99124eeb017becfcb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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