1-(4-Chlorophenyl)-3-methylthiourea → HCID 20527226, compound

HRID 67768Notes

Reaction equation

HRID 67768 reaction equation
C(N(CC)S(C1C=C(C(=O)C[Br:16])C=CC=1Cl)(=O)=O)C.ClC1C=CC(NC(NC)=S)=CC=1.Br.[CH2:33]([N:35]([CH2:61][CH3:62])[S:36]([C:39]1[CH:40]=[C:41]([C:46]2(O)[CH2:50][S:49][C:48](=[N:51][C:52]3[CH:57]=[CH:56][C:55]([Cl:58])=[CH:54][CH:53]=3)[N:47]2[CH3:59])[CH:42]=[CH:43][C:44]=1[Cl:45])(=[O:38])=[O:37])[CH3:34]>C(O)(=O)C>[BrH:16].[CH2:61]([N:35]([CH2:33][CH3:34])[S:36]([C:39]1[CH:40]=[C:41]([C:46]2[N:47]([CH3:59])[C:48](=[N:51][C:52]3[CH:53]=[CH:54][C:55]([Cl:58])=[CH:56][CH:57]=3)[S:49][CH:50]=2)[CH:42]=[CH:43][C:44]=1[Cl:45])(=[O:38])=[O:37])[CH3:62]

Participants

5

Reactant 3

HCID 6982961-(4-Chlorophenyl)-3-methylthioureaHCID 20527448HCID 20527448, compoundHCID 705519474-(3-Diethylsulfamoyl-4-chlorophenyl)-2-(4-chlorophenyl-imino)-3-methylthiazolidin-4-ol hydrobromide

Product 1

HCID 20527226HCID 20527226, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Obtained (a) by a procedure analogous to that indicated in Example 1(a), from 3'-diethylsulfamoyl-2-bromo-4'-chloroacetophenone and 1-(4-chlorophenyl)-3-methylthiourea, or (b) by a procedure analogous to that of Example 1(b), by boiling 4-(3-diethylsulfamoyl-4-chlorophenyl)-2-(4-chlorophenyl-imino)-3-methylthiazolidin-4-ol hydrobromide for 2 hours in glacial acetic acid and filtering off the crystals after cooling. Melting point 207° C. (with decomposition).

Workup

  1. customfor 2 hours
  2. filtrationfiltering off the crystals
  3. temperatureafter cooling

Sources & evidence

ORD record
ord-f05d7fd14a754441ad3622ac1dc78b63
Source dataset
uspto-grants-1982_08
Patent number
US04346088

Reaction notes

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