4-[4-Chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol → HCID 20527446, compound

HRID 67774Notes

Reaction equation

HRID 67774 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2(O)[CH2:12][S:11][C:10](=[N:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:9]2[CH3:20])=[CH:4][C:3]=1[S:22]([N:25]1[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]1)(=[O:24])=[O:23]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH3:20])[C:10](=[N:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[S:11][CH:12]=2)=[CH:4][C:3]=1[S:22]([N:25]1[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]1)(=[O:24])=[O:23]

Participants

3

Reactant 1

HCID 205273194-[4-Chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol

Product 1

HCID 20527446HCID 20527446, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Obtained by a procedure analogous to that indicated in Example 2(b), from 4-[4-chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol, by boiling with glacial acetic acid and subsequently distilling off the solvent. Water is added to the residue and the pH is adjusted to 13 with 2 N NaOH. The crystals are filtered off and recrystallized from isopropanol. Melting point 156°-158° C.

Workup

  1. customObtained by a procedure analogous to
  2. distillationsubsequently distilling off the solvent
  3. additionWater is added to the residue
  4. filtrationThe crystals are filtered off
  5. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-52454aec7538443d8cdbf3408d54c17f
Source dataset
uspto-grants-1982_08
Patent number
US04346088

Reaction notes

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