Dichloromethane → 6-[Chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one

HRID 677758Notes

Reaction equation

HRID 677758 reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:37])[n:11]([CH2:33][CH:34]3[CH2:35][CH2:36]3)[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[n:20]([CH3:24])[cH:21][n:22][cH:23]4)([OH:25])[c:26]4[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]4)[cH:16][c:17]23)[cH:5][cH:6][cH:7]1.[Cl:42][CH2:43][Cl:44].[S:38]([Cl:39])([Cl:40])=[O:41]>>[Cl:1][c:2]1[cH:3][c:4](-[c:8]2[cH:9][c:10](=[O:37])[n:11]([CH2:33][CH:34]3[CH2:35][CH2:36]3)[c:12]3[cH:13][cH:14][c:15]([C:18]([c:19]4[n:20]([CH3:24])[cH:21][n:22][cH:23]4)([c:26]4[cH:27][cH:28][c:29]([Cl:32])[cH:30][cH:31]4)[Cl:40])[cH:16][c:17]23)[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 99149464-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-cyclopropylmethyl-1H-quinolin-2-one

Product 1

HCID 183790276-[Chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-chloro-phenyl)-1-cyclopropylmethyl-1H-quinolin-2-one

Sources & evidence

ORD record
ord-894bfa99286a4beb96b2ad2d76eeae40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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