Toluene → N-{2-Chloro-3-[5-(2-methyl-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

HRID 678098Notes

Reaction equation

HRID 678098 reaction equation
[CH2:48]1[O:49][CH2:50][CH2:51][O:52][CH2:53]1.[CH3:38][Zn:39][CH3:40].[CH3:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1.[Cl:1][c:2]1[c:3]([NH:26][S:27](=[O:28])(=[O:29])[c:30]2[c:31]([F:37])[cH:32][cH:33][c:34]([F:36])[cH:35]2)[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[s:11][c:12]1-[c:13]1[n:14][c:15]([Cl:19])[n:16][cH:17][cH:18]1>>[Cl:1][c:2]1[c:3]([NH:26][S:27](=[O:28])(=[O:29])[c:30]2[c:31]([F:37])[cH:32][cH:33][c:34]([F:36])[cH:35]2)[cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[s:11][c:12]1-[c:13]1[n:14][c:15]([CH3:38])[n:16][cH:17][cH:18]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 312751,4-DioxaneHCID 57989857N-{2-Chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamideHCID 178477796HCID 178477796, compound

Product 1

HCID 57989839N-{2-Chloro-3-[5-(2-methyl-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-8af9442d4f4142a09d9b4ebb833e7d89
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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