2,5-Difluorobenzenesulfonyl chloride → N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,5-difluorobenzenesulfonamide

HRID 678193Notes

Reaction equation

HRID 678193 reaction equation
[Cl:1][c:2]1[n:3][c:4](-[c:5]2[s:6][c:7]([CH:8]([CH3:9])[CH3:10])[n:11][c:12]2-[c:13]2[cH:14][c:15]([NH:16][S:17]([c:18]3[c:19]([F:20])[cH:21][cH:22][cH:23][c:24]3[F:25])(=[O:26])=[O:27])[cH:28][cH:29][cH:30]2)[cH:31][cH:32][n:33]1.[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39](-[c:41]2[c:42](-[c:52]3[c:53]([F:60])[c:54]([NH2:55])[cH:56][cH:57][c:58]3[F:59])[n:43][c:44]([N:46]3[CH2:47][CH2:48][O:49][CH2:50][CH2:51]3)[s:45]2)[n:40]1.[F:61][c:62]1[c:63]([S:69](=[O:70])(=[O:71])[Cl:72])[cH:64][c:65]([F:68])[cH:66][cH:67]1>>[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39](-[c:41]2[c:42](-[c:52]3[c:53]([F:60])[c:54]([NH:55][S:69]([c:63]4[c:62]([F:61])[cH:67][cH:66][c:65]([F:68])[cH:64]4)(=[O:70])=[O:71])[cH:56][cH:57][c:58]3[F:59])[n:43][c:44]([N:46]3[CH2:47][CH2:48][O:49][CH2:50][CH2:51]3)[s:45]2)[n:40]1

Participants

4

Reactant 3

HCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 57989700HCID 57989700, compoundHCID 57990030N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989715N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-dfca1231c0bb4133a6bd605e0db91159
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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