N-Methylethylenediamine → HCID 178484314, compound

HRID 67916Notes

Reaction equation

HRID 67916 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[NH:16][CH:15]=[N:14][C:13]=1[CH3:17])SC)#[N:2].[NH2:18][CH2:19][CH2:20][NH:21][CH3:22]>>[C:1]([NH:3][C:4]([NH:18][CH2:19][CH2:20][NH:21][CH3:22])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[NH:16][CH:15]=[N:14][C:13]=1[CH3:17])#[N:2]

Participants

3

Reactant 2

HCID 8014N-MethylethylenediamineHCID 178503877HCID 178503877, compound

Product 1

HCID 178484314HCID 178484314, compound

Procedure

N-Cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (5.4 g) and (2-aminoethyl)methylamine (25 ml) were mixed together and left for 15 hours at 20° C. Evaporation to dryness and azeotroping with acetonitrile to remove excess diamine gave a solid residue which was recrystallised from isopropanol to give the title compound (4.8 g), m.p. 146°-148° C.

Workup

  1. customEvaporation to dryness
  2. customazeotroping with acetonitrile
  3. customto remove excess diamine
  4. customgave a solid residue which
  5. customwas recrystallised from isopropanol

Sources & evidence

ORD record
ord-8597a0ce9b5f464caece62117024b630
Source dataset
uspto-grants-1982_08
Patent number
US04347250

Reaction notes

Loading…