Ethylamine → 2-(Ethylamino)nicotinonitrile

HRID 67952Notes

Reaction equation

HRID 67952 reaction equation
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH2:10]([NH2:12])[CH3:11]>O>[CH2:10]([NH:12][C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:11]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 810792-Chloronicotinonitrile

Product 1

HCID 155809442-(Ethylamino)nicotinonitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A stirred mixture of 4 g. of 2-chloronicotinonitrile in 200 ml. of a saturated ethanolic ethylamine solution was heated under reflux for 5 hours. The solution was cooled and was diluted with 400 ml. of water. The precipitate of 2-ethylaminonicotinonitrile which formed was collected, air dried and was used directly in the next step without further purification.

Workup

  1. additionA stirred mixture of 4 g
  2. temperatureunder reflux for 5 hours
  3. temperatureThe solution was cooled
  4. additionwas diluted with 400 ml

Sources & evidence

ORD record
ord-cbd57385fc3e447bbd56d4c7a65f522b
Source dataset
uspto-grants-1982_08
Patent number
US04347362

Reaction notes

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