3-(4-Aminophenyl)-1,4-dimethylpiperazin-2-one → N-(2-{2-[4-(1,4-Dimethyl-3-oxo-piperazin-2-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-N-methyl-methanesulfonamide

HRID 679751Notes

Reaction equation

HRID 679751 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[N:5]([c:6]1[c:7](-[c:12]2[cH:13][cH:14][c:15]3[cH:16][n:17][c:18]([O:21][S:22]([C:23]([F:24])([F:25])[F:26])(=[O:27])=[O:28])[n:19][n:20]23)[cH:8][cH:9][cH:10][cH:11]1)[CH3:29].[NH2:30][c:31]1[cH:32][cH:33][c:34]([CH:37]2[C:38](=[O:45])[N:39]([CH3:44])[CH2:40][CH2:41][N:42]2[CH3:43])[cH:35][cH:36]1>>[CH3:1][S:2](=[O:3])(=[O:4])[N:5]([c:6]1[c:7](-[c:12]2[cH:13][cH:14][c:15]3[cH:16][n:17][c:18]([NH:30][c:31]4[cH:32][cH:33][c:34]([CH:37]5[C:38](=[O:45])[N:39]([CH3:44])[CH2:40][CH2:41][N:42]5[CH3:43])[cH:35][cH:36]4)[n:19][n:20]23)[cH:8][cH:9][cH:10][cH:11]1)[CH3:29]

Participants

3

Reactant 2

HCID 576251203-(4-Aminophenyl)-1,4-dimethylpiperazin-2-oneHCID 86661681Trifluoro-methanesulfonic acid 7-[2-(methanesulfonyl-methyl-amino)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl ester

Product 1

HCID 66711921N-(2-{2-[4-(1,4-Dimethyl-3-oxo-piperazin-2-yl)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-N-methyl-methanesulfonamide

Sources & evidence

ORD record
ord-0e9db1bd619c435cb9b7f911447be631
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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