Ethylamine → HCID 178464587, compound

HRID 67977Notes

Reaction equation

HRID 67977 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15](=[N:18][C:19]#[N:20])SC)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH2:21]([NH2:23])[CH3:22]>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:23][CH2:21][CH3:22])=[N:18][C:19]#[N:20])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 178503927HCID 178503927, compound

Product 1

HCID 178464587HCID 178464587, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-guanidino-4-[2-(3-cyano-2-methylisothioureido)ethylthiomethyl]thiazole (1.1 g.) in ethanol (25 ml.) was treated with 70% w/v aqueous ethylamine (5 ml.) at room temperature. The mixture was stirred overnight at room temperature and the solution evaporated to dryness. The residue was crystallized from methanol to give 2-guanidino-4-[2-(2-cyano-3-ethylguanidino)ethylthiomethyl]thiazole (0.53 g.), m.p. 181°-182° C.

Workup

  1. customthe solution evaporated to dryness
  2. customThe residue was crystallized from methanol

Sources & evidence

ORD record
ord-6006dfbcf552445991692075dbd0b76d
Source dataset
uspto-grants-1982_08
Patent number
US04347370

Reaction notes

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