反应详情

A solution of 2-guanidino-4-[2-(3-methylthioureido)ethylthiomethyl]thiazole hydrogen maleate (0.42 g.) in ethanol (15 ml.) was treated with methyl iodide (0.175 g.). The clear solution was heated under reflux on a steam bath for 1.5 hours, cooled and the volume reduced to 5 ml. by evaporation under reduced pressure. The insoluble material was filtered and recrystallized from ethanol to give 2-guanidino-4-[2-(2,3-dimethylisothioureido)ethylthiomethyl]thiazole hydrogen maleate hydriodide. Found: C, 30.2; H, 4.1; N, 14.8; S, 17.2. C14H23IN6O4S3 requires C, 29.94; H, 4.09; N, 14.97; S, 17.11%

1. temperatureThe clear solution was heated
2. temperatureunder reflux on a steam bath for 1.5 hours
3. temperaturecooled
4. customby evaporation under reduced pressure
5. filtrationThe insoluble material was filtered
6. customrecrystallized from ethanol