反应详情

6 g of 3,5-dibromo-2,4-dihydroxy-benzaldoxime were dissolved in 50 ml of dimethylsulfoxide and a little diazabicyclooctane was added. 4 ml of methyl isocyanate were now added with cooling (<20° C.) and stirring and the mixture was then stirred thoroughly at room temperature for 12 hours. The reaction mixture was poured into ice-water and salted out. The suspension was filtered with suction, the residue was washed with water and dissolved in a little dimethylformamide and active charcoal was added to the solution.

1. temperaturewith cooling (<20° C.)
2. stirringthe mixture was then stirred thoroughly at room temperature for 12 hours
3. filtrationThe suspension was filtered with suction
4. washthe residue was washed with water
5. dissolutiondissolved in a little dimethylformamide and active charcoal
6. additionwas added to the solution