Acetic Acid → HCID 136408869, compound

HRID 67993Notes

Reaction equation

HRID 67993 reaction equation
[C:1]([CH2:3][C:4]1[S:5][C:6]([S:9][CH3:10])=[N:7][N:8]=1)#[N:2].C(O)(=O)C.[N:15]([O-])=[O:16].[Na+]>O>[CH3:10][S:9][C:6]1[S:5][C:4]([C:3](=[N:15][OH:16])[C:1]#[N:2])=[N:8][N:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 201559012-Cyanomethyl-5-methylthio-1,3,4-thiadiazoleHCID 23668193Sodium Nitrite

Product 1

HCID 136408869HCID 136408869, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

17.1 g (0.1 mol) of 2-cyanomethyl-5-methylthio-1,3,4-thiadiazole are intially introduced into 75 ml of glacial acetic acid. A solution of 7.8 g (0.11 mol) of NaNO2 in 20 ml of water is added dropwise and the mixture is stirred for 1 hour. 200 ml of water are then added to the solution and the mixture is filtered. The residue is washed with water: 19 g (95% of theory) of end product, melting point >200° C. (decomposition).

Workup

  1. filtrationthe mixture is filtered
  2. washThe residue is washed with water

Sources & evidence

ORD record
ord-47d0c987fc6e4bf885970687259de0a5
Source dataset
uspto-grants-1982_08
Patent number
US04347372

Reaction notes

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