2-Thiophenecarboxylic acid → N-Ethyl-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-2-thiophenecarboxamide

HRID 680056Notes

Reaction equation

HRID 680056 reaction equation
[CH2:9]([CH3:10])[NH:11][CH2:12][C:13]([C:14]([F:15])([F:16])[F:17])([OH:18])[CH2:19][NH:20][c:21]1[c:22]2[cH:23][n:24][n:25](-[c:31]3[cH:32][cH:33][c:34]([F:37])[cH:35][cH:36]3)[c:26]2[cH:27][c:28]([CH3:30])[cH:29]1.[s:1]1[c:2]([C:6](=[O:7])[OH:8])[cH:3][cH:4][cH:5]1>>[s:1]1[c:2]([C:6](=[O:8])[N:11]([CH2:9][CH3:10])[CH2:12][C:13]([C:14]([F:15])([F:16])[F:17])([OH:18])[CH2:19][NH:20][c:21]2[c:22]3[cH:23][n:24][n:25](-[c:31]4[cH:32][cH:33][c:34]([F:37])[cH:35][cH:36]4)[c:26]3[cH:27][c:28]([CH3:30])[cH:29]2)[cH:3][cH:4][cH:5]1

Participants

3

Reactant 2

HCID 107002-Thiophenecarboxylic acidHCID 593241453-(Ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol

Product 1

HCID 59324168N-Ethyl-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]-2-thiophenecarboxamide

Sources & evidence

ORD record
ord-a27d5b152b2349a8961b34780a27197e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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