3-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid → N-[3-(2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl)-4-fluorophenyl]-3-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Reaction equation
[F:19][C:20]([CH2:21][O:22][c:23]1[c:24]([C:29](=[O:30])[OH:31])[n:25][cH:26][cH:27][cH:28]1)([F:32])[F:33].[NH2:1][c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([F:18])[c:6]([C:8]2([CH3:17])[N:9]=[C:10]([NH2:16])[O:11][CH2:12][C:13]2([F:14])[F:15])[cH:7]1)[C:29]([c:24]1[c:23]([O:22][CH2:21][C:20]([F:19])([F:32])[F:33])[cH:28][cH:27][cH:26][n:25]1)=[O:30]Participants
3
Sources & evidence
- ORD record
- ord-27770b236af1420f80996e22e5ca52a2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
Loading…