Dimethylamine → N,N,4-trimethyl-6-nitroquinolin-2-amine

HRID 6808Notes

Reaction equation

Cl[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1.[CH3:16][NH:17][CH3:18].CO>>[CH3:16][N:17]([CH3:18])[C:2]1[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1

Participants

Reactant 3

HCID 674Dimethylamine

HCID 887Methanol

HCID 3284312-Chloro-4-methyl-6-nitroquinoline

Product 1

HCID 22018963N,N,4-trimethyl-6-nitroquinolin-2-amine

Procedure

The product was obtained from the product of Step A and a solution of 2N dimethylamine in methanol (5 mL, 25 mmol) according to the procedure of Example 1, Step C.

Sources & evidence

ORD record: ord-0cd5609f1a754f3db695d5fd5eadc6e8
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07084156B2

Reaction notes

Loading…